Home

Nodular melanoma pathology outlines

Pathology Outlines - Invasive melanom

  1. 8720/3 - Malignant melanoma, NOS 8746/3 - Mucosal lentiginous melanoma 8721/3 - Nodular melanoma 8780/3 - Blue nevus, malignant 8761/3 - Malignant melanoma in giant pigmented nevus 8771/3 - Epithelioid cell melanoma 8773/3 - Spindle cell melanoma, type A 8774/3 - Spindle cell melanoma, type B 8720/6 - Malignant melanoma, metastati
  2. Differs from cutaneous melanoma due to lack of association with sun damage, family history or atypical nevi and difference in prognostic factors Nodal and distant metastases are common References: Am J Surg Pathol 2001;25:782, Am J Surg Pathol 2002;26:88
  3. 33 year old Japanese woman with clear cell variant (Gynecol Oncol 2001;80:409) 39 year old woman with vaginal bleeding (Indian J Cancer 2005;42:201) 63 year old woman with S100 negative tumor (Int J Gynecol Pathol 1999;18:265) 67 year old woman with vaginal bleeding (Anticancer Res 2003;23:1063) Patient with radiation induced malignant melanoma (Clin Oncol (R Coll Radiol) 2000;12:234

Definition / general. Melanoma constitutes about 4 - 10% of all vulvar malignancies ( Int J Gynecol Cancer 2013;23:1118 ) Second most common malignant vulvar neoplasm after squamous cell carcinoma. Melanoma may originate in vaginal wall without involvement of vulva, uterine cervix or other surrounding structures ( Gynecol Obstet 2013;3:183 Nodular melanoma (NM) presents as a rapidly enlarging nodule. Histologically there is a dermal mass of dysplastic tumour cells with upward epidermal invasion but minimal adjacent epidermal spread or horizontal growth. Tumour cells are often round and epithelioid in morphology with hyperchromatic nuclei. See Figure 16, 17 Malignant melanoma, also melanoma, is an aggressive type of skin cancer that can be diagnostically challenging for pathologists. It fits into the larger category of melanocytic lesions which includes many benign entities, a number of which can be difficult to distinguish from melanoma Nodular melanoma can resemble a skin-coloured or pink melanocytic naevus (mole) or basal cell carcinoma. With subungal melanoma, 25% are amelanotic. With desmoplastic melanoma, over 50% are amelanotic. Metastatic melanoma not uncommonly presents with amelanotic lesions even when the primary lesion is pigmented Desmoplastic melanoma is a rare form of invasive melanoma, a skin cancer that arises from pigment cells (melanocytes). Desmoplastic melanoma often involves nerve fibres, when it is called neurotropic melanoma. The malignant cells within the dermis are surrounded by fibrous tissue

Pathology Outlines - Oral mucosal melanom

The Clark Scale has five levels: Level 1: Melanoma is confined to the epidermis (the outer layer of the skin). Level 2: Melanoma has invaded the papillary dermis (the outermost layer of the dermis, the next layer of skin). Level 3: Melanoma has invaded throughout the papillary dermis and is touching on the next, deeper layer of the dermis Nodular melanoma is a deadly type of skin cancer that typically appears on the areas of skin most exposed to the sun such as the legs, chest, back, arms and head. This type of melanoma usually appears as a round, black bump, but it can also look like a mole or even a pimple with no pus inside Nodular melanomas share many histologic features with superficial spreading melanomas, but differ in one significant way. Unlike the situation in most superficial spreading melanomas, nodular..

Nodular melanoma is an invasive form of melanoma characterized by relatively rapid vertical growth. Melanomas that arise in the eye are known as uveal, or ocular, melanomas. Melanoma, known as mucosal melanoma, can also arise from mucosal surfaces such as the lips, eyelids, vulva, penis or anus. View chapter Purchase boo Melanocytic matricoma is a rare tumour that presents as a small heavily pigmented tumour. It clinically mimics nodular melanoma, haemangioma and other pigmented tumours. So far, these tumours have exhibited a benign clinical course. Histology of melanocytic matricom Dataset for histopathological reporting of primary cutaneous malignant melanoma and regional lymph nodes. Cellular pathology ; Datasets; February 201

Mucosal melanoma of the nasal cavity and paranasal sinuses is a rare disease, but its incidence appears to be increasing. The mean age at diagnosis is between 65 and 70 years. Unilateral nasal obstruction and epistaxis are the most common presenting complaints. Melanoma arises in the septum or later Background. Malignant melanoma could present with metastasis with unknown primary (MUP) and this happens in 2-3% according to the studies. Around 90% of melanomas have cutaneous origin, but still there are melanomas that could be found in visceral organs or lymph nodes with unknown primary site. Spo

Pathology Outlines - Malignant melanom

Spindle cell melanoma is a rare histological variant of melanoma, characterised by the presence of spindle-shaped melanocytes [1]. On microscopy, it is often mistaken for other skin and soft tissue cancers with spindle cell morphologies. Desmoplastic melanoma is a variant of spindle cell melanoma where there are varying proportions of spindle. Just like other subtypes, nodular melanoma develops in the skin cells that produce melanin, that pigment that gives the skin its color. Nodular melanoma accounts for about 15% of all skin cancer cases and it is the most aggressive form of melanoma 5. Nodular melanoma can affect both the young and the old but it is more common in older people Visual survey of surgical pathology with 11147 high-quality images of benign and malignant neoplasms & related entities. Melanoma - Clinico-Pathologic Subtypes Focused Melanoma - Clinico-Pathologic Subtypes with stained slides of pathology Massive nodular melanoma: A case report Mandy Harting MD 1, William Tarrant MD 2, Craig A Kovitz MD 3, Ted Rosen MD 1, Matthew T Harting MD 2, Eduardo Souchon MD 2 Dermatology Online Journal 13 (2): 7 1. Baylor College of Medicine, Department of Dermatology, Houston, Texas2. University of Texas Medical School at Houston, Department of Surgery, Houston, Texas 3

Pathology Outlines - Melanom

Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas from these other tumors; it has also been studied for use as an adjunct to distinguish benign and malignant melanocytic tumors and to elucidate prognosis Sry-related HMg-Box gene 10 (SOX10) is a nuclear transcription factor that plays an important role in melanocytic cell differentiation. It has been shown to be a sensitive marker of melanoma including spindle and desmoplastic subtypes. We assessed its frequency of expression in melanoma, carcinoma, Type of Melanoma. Also called the histologic type or cellular type of melanoma. There are four major subtypes, with a few rare subtypes: Superficial Spreading Melanoma: most common of the melanomas. Nodular Melanoma: are always vertical growth phase present (see below) melanomas. Most commonly found on the chest, back, head or neck ↑ Christopher S. Hale. Skin melanocytic tumor - Melanoma - Invasive melanoma. Pathology Outlines. Topic Completed: 1 May 2013. Revised: 17 September 2019 ↑ 7.0 7.1 Measurements used to classify a melanoma as radical: Page 406 in: Klaus J. Busam, Richard A Scolyer, Pedram Gerami (2018). Pathology of Melanocytic Tumors. Elsevier Health Sciences The surface architecture varies for oral melanomas ranging from nodular and macular to ulcerated. [4,5,7] Amelanotic oral malignant melanoma (AOMM) : some tumors are amelanotic which is of rare type. lesion is erythematous or pink,sometimes it may be eroded or nodule. but the diagnosis of the lesion may be confused with other tumors, only by the histopathological examination the final diagnosis of the lesion can be made

Melanoma of the small intestine can be metastatic in patients with a history of a cutaneous, anal, or ocular melanoma. Metastatic intestinal melanoma is very common, and among affected patients, the proportion with involvement of the small intestine ranges from 35% to 70%. 2. Washington K. McDonagh D nodular melanoma. lentigo maligna (in situ at junction) lentigo maligna melanoma (has vertical growth phase) regressing melanoma (lichenoid regression of lentigo maligna) spindle cell melanoma. desmoplastic melanoma. metastatic melanoma. clear cell sarcoma

True rectal melanoma is exceedingly rare. Metastasis must be ruled out clinically or by identification of a junctional component. Poor prognosis. Most recurrences are systemic. 5-25% 5 year survival. Teri A Longacre MD longacre@stanford.edu. Robert V Rouse MD rouse@stanford.edu. Department of Pathology. Stanford University School of Medicine One hundred and three cases of Spitz nevi were reviewed, 36% of these patients were adults. The lesions in children occurred primarily on the face and secondarily on the trunk followed by the extremities. In adults, they affect the legs in women, and the trunk in men as does malignant melanoma. Clin Drs. Skala, Wang, Harms, Andea, Fullen and Chan in the Department of Pathology Dermatopathology section, in collaboration with other U-M colleagues, have published the paper, Comprehensive Histopathologic Comparison of Epidermotropic/Dermal Metastatic Melanoma and Primary Nodular Melanoma in Histopathology. Metastatic melanoma involving the. Melanoma and Melanoma In-Situ Diagnosis after Excision of Atypical Intraepidermal Melanocytic Proliferation •Retrospective Pathology Report •Nodular Malignant Melanoma 2.5mm Note: metastatic melanoma cannot be excluded. Primary Nodular vs Epidermotropic Metastasis

Video: Melanoma pathology DermNet N

Malignant melanoma - Libre Patholog

  1. A nodular melanoma developing within an amelanotic melanoma in situ on the scalp. for benign moles, scars or cysts. This can delay diagnosis, which may prove dangerous, since early detection of melanoma is critical; early melanomas are almost always curable, while those that advance beyond stage I become more difficult to treat. Amelanotic.
  2. Pathology Outlines - Nodular melanoma. photograph Webpathology.com: A Collection of Surgical Pathology Images. photograph Histologic criteria for diagnosing primary cutaneous. photograph Untitled Flashcards at New York University School of. photograph Malignant Melanoma at 10x Magnification | MicroscopyU
  3. antly.
  4. Type of Melanoma. Also called the histologic type or cellular type of melanoma. There are four major subtypes, with a few rare subtypes: Superficial Spreading Melanoma: most common of the melanomas. Nodular Melanoma: are always vertical growth phase present (see below) melanomas. Most commonly found on the chest, back, head or neck
  5. skin - typically head & neck. Prevalence. very rare. Prognosis. poor. Treatment. surgical excision. Porocarcinoma is a rare malignant skin tumour that has an aggressive behaviour. It is also known as eccrine porocarcinoma (abbreviated EPC) and malignant eccrine poroma
  6. In: Barnhill RL, Piepkorn M, Busam KJ (eds) Pathology of melanocytic nevi and malignant melanoma. Butterworth-Heinemann, Boston, p 195 Google Scholar Busam KJ, Iversen K, Coplan KC, Jungbluth AA (2001) Analysis of microphthalmia transcription factor expression in normal tissues and tumors, and comparison of its expression with S-100 protein.

Epithelioid Malignant Peripheral Nerve Sheath Tumor Composed primarily of Schwann cells with a polygonal epithelioid appearance; No association with NF1; Up to 80% of tumors show strong, diffuse S-100 staining Do not express melanoma markers and only rarely express keratin Although diffuse PRAME expression is generally limited to malignant melanoma, benign Spitz nevi and atypical Spitz tumors can infrequently express diffuse PRAME. PRAME immunohistochemistry can be useful in the evaluation of atypical melanocytic proliferations with intermediate histopathologic features but should be interpreted with caution in. Superficial spreading melanoma is the most common type of melanoma. It starts off by growing along the top layer of the skin. Eventually, it can penetrate deeper into the skin. Learn more about superficial spreading melanoma. Nodular melanoma is the second most common type of melanoma. It can be aggressive because it usually grows quickly Melanocytic schwannoma or malignant melanoma? Journal of clinical pathology.53:318-20. Carney JA (1990) Psammomatous melanotic schwannoma. A distinctive, heritable tumor with special associations, including cardiac myxoma and the Cushing syndrome. The American journal of surgical pathology.14(3):206-22 The atypical melanocytes have pleomorphic hyperchromatic nuclei, prominent nucleoli, and show frequent mitoses. Both in-situ and invasive component usually show spindle morphology. Some acral melanomas have superficial spreading in-situ component or show nodular features in invasive tumor. This tumor was present on the heel of an elderly male

Amelanotic melanoma DermNet N

Klaus J. Busam, in Pathology of Melanocytic Tumors, 2019. Melanosis Associated With Metastatic Melanoma. Melanosis can be localized and diffuse. Some lesions of metastatic melanoma may be composed entirely of melanophages without viable melanoma cells (Fig. 27.21, see Fig. 27.13). This may occur in response to treatment or host inflammatory. Definition (NCI) A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma Using the example of the three most common skin (cancers basal cell carcinoma, squamous cell carcinoma and malignant melanoma), this review outlines how the contents of the histopathology report influence patient management. Recently, unravelling the molecular pathogenesis of some of these tumours has paved the way for development of novel. Melanoma, an aggressive skin cancer, is currently the fifth most commonly diagnosed cancer in men and seventh in women in the United States with its incidence increasing 194 percent from 1975 to 2011. 1, 2 In 2014, approximately 76,100 patients will be diagnosed with melanoma in the United States, accounting for an estimated 9,710 deaths. 1 Though recent advances in therapies for metastatic. Fletcher CDM, Unni KK, Mertens F. Pathology and Genetics of Tumours of Soft Tissue and Bone, World Health Organization Classification of Tumours 2002; Weiss SW, Goldblum JR. Enzinger and Weiss's Soft Tissue Tumors, 4th edition, 2001; Chung EB, Enzinger FM. Malignant melanoma of soft parts. A reassessment of clear cell sarcoma

Desmoplastic melanoma DermNet N

Breslow Depth and Clark Level - Melanoma Research Allianc

Pigmented Villonodular Synovitis is a locally aggressive neoplastic synovial disease (not a true neoplasm) characterized by joint effusions, expansion of the synovium, and bony erosions. The condition usually presents in patients between 30 and 40 years old with recurrent atraumatic knee hemarthrosis. Diagnosis is multifaceted with clinical. Vimentin. From Libre Pathology. Jump to navigation Jump to search. Vimentin staining in a poorly differentiated carcinoma. Vimentin staining in a lymphoma. Vimentin is a common immunostain. It marks most soft tissue lesions and malignant melanoma. It is usually negative in carcinomas IHC. Metastases are typically negative for HepPar-1.. HepPar-1 (hepatocytes paraffin antibody 1) - labels hepatocellular mitochondria.; A panel: CK7, CK20, TTF-1, CDX2, CA-125. Note: If a primary is already established by pathology and it isn't breast, and the clinical impression is a metastasis, it isn't necessary to do IHC if the morphology of the lesion in the liver is compatible with the. 3.2.2. Narrations from Reported Cases of Melanoma of the Urinary Bladder. Kerley et al. [] reported an 80-year-old woman who developed vulvar melanosis and malignant melanoma of the labia majora and clitoris and she underwent simple vulvectomy.She subsequently developed melanosis of the urinary bladder and she presented 3 years later with multifocal malignant melanoma which involved the vagina.

Polypoid nodular melanoma | Mooi

What's So Different About Nodular Melanoma? U

melanoma. superficial spreading melanoma; nodular melanoma; lentigo maligna; acral lentiginous melanoma; desmoplastic melanoma; childhood melanoma; nevoid melanoma; melanoma arising from blue nevus; melanoma arising in giant congenital nevi; regressing melanoma; spindle cell melanoma; clear cell sarcoma. benign melanocytic nevus. by layer. Collaborative Ocular Melanoma Study (COMS) staging of melanoma of the eye The TNM system is very detailed, but in practice doctors may use the simpler staging system devised by the COMS group, which has done most of the clinical research on how to treat intraocular melanoma. This system divides eye melanomas into small, medium, and large Choroidal melanoma has a very rare incidence in Africa and Asia, especially in the Middle East. We report the first case of choroidal melanoma in Lebanon in a 33-year-old man presenting with progressive loss of vision in his right eye. MRI showed retinal detachment with evidence of a nodular-like lesion most consistent with choroidal melanoma This review outlines recent advances in our understanding of CSPG4‐associated cell signaling, describing the central role it plays in melanoma tumor cell growth, motility, and survival, and explores how modifying CSPG4 function and protein-protein interactions may provide us with novel combinatorial therapies for the treatment of advanced.

Pathology Outlines - Invasive melanoma

Nested melanoma. To the editor: The recent paper by Heinz Kutzner and co-authors introduces a new variant of superficial spreading melanoma composed predominantly of large hypercellular nests of. Melanoma (S100+) adenoid SCC (acantholytic SCC, pseudoglandular SCC) gland like changes but negative for mucin or CEA. adenosquamous SCC. goblet cells positive for mucin and CEA. lymphoepithelioma like carcinoma. dense lymphocytic nodules +/- germinal centers; islands of squamous cells. Grading. well differentiated. resembles normal squa the malignant melanoma of soft parts (MMSP) preferentially occurs in young adults, between ages of 20 and 40 years; the tumour develops mainly in the extremities, especially the legs (foot, knee, heel, ankle); it is usually deeply seated, and often bound to tendons and aponeuroses: Pathology Hi, in human serum for Malignant melanoma you can used a protein S-100 as a tumor marker.This marker has a good results. Cite. 2 Recommendations. 7th Oct, 2014. Daniel Wehrung Melanoma, also redundantly known as malignant melanoma, is a type of skin cancer that develops from the pigment-producing cells known as melanocytes. Melanomas typically occur in the skin but may rarely occur in the mouth, intestines or eye (uveal melanoma).In women, they most commonly occur on the legs, while in men they most commonly occur on the back

A yellow-white lesion that can be diffuse or focal, sometimes with diffuse ulceration, conjunctival injection, or madarosis (lash loss) Arise from sebaceous glands (meibomian, glands of Zeiss, in the caruncle) Aggressive tumor that can metastasize; worse survival rates than squamous cell carcinoma Differential diagnosis (1) Heavily pigmented melanoma: So-called 'animal'-type melanoma is a rare subtype of melanoma that has clinicopathological features similar to the heavily pigmented melanocytic tumours found in grey horses and other animals.It was first designated as melanosarcoma by Darier in 1925,1 but has also been called animal-type or equine-type melanoma, pigment-synthesising. Preferentially expressed antigen of melanoma (PRAME) is a 509-amino-acid protein originally identified as an antigen recognized by cytotoxic T lymphocytes from a patient with melanoma. 4-6 The tumor antigen PRAME is a nonmutated gene whose expression is mostly restricted to tumor cells, as most normal tissues do not express PRAME, the. Nodular fasciitis is a self-limited myofibroblastic lesion that can be misdiagnosed as a sarcoma as a result of its rapid growth, cellularity, and sometimes prominent mitotic activity. A recurrent.

Lentigo maligna melanoma is a type of invasive skin cancer. It develops from lentigo maligna, which is sometimes called Hutchinson's melanotic freckle. Lentigo maligna stays on the outer surface. Skin adenocarcinoma pathology outlines Pathology Outlines - Digital papillary adenocarcinom Vulva, and Penis; Excludes Melanoma): Resection Patient name: WebPathology is a free educational resource with 11159 high quality pathology images of benign and malignant neoplasms and related entities. Visual survey of surgical pathology with.

Histologic criteria for diagnosing - Modern Patholog

  1. , human melanoma black-45 (HMB-45), chromogranin, and synaptophysin (Figures 3(a) and 3(b)). The histopathological diagnosis was consistent with malignant glomus tumor of the intestinal ileum
  2. Nasal mucosal melanosis may act as a harbinger of melanoma: A case report William C. Yao, M.D.,1,2 Kevin S. Emerick, M.D., 2Stefan Kraft, M.D.,3 and Eric H. Holbrook, M.D. ABSTRACT Background: The progression from a benign pigmented lesion on the skin to cutaneous melanoma is better understood, and it could be presumed that a similar progression occurs with mucosal lesions
  3. ___ Spitz melanoma (malignant Spitz tumor) ___ Nodular melanoma ___ Nevoid melanoma ___ Melanoma, not otherwise classified ___ Other histologic type not listed (specify): _____ In order to represent this appropriately in the pathology report, information from prior procedures may be incorporated into th
  4. er for the RCPath Diploma in Dermatopathology and Senior Clinical Scientist CRUK, Manchester Institute
  5. a. superficial spreading melanoma b. nodular melanoma c. lentigo maligna d. acral-lentiginous melanoma e. desmoplastic melanoma f. nevoid melanoma g. amelanotic melanoma 3. Appendageal tumors a. tubular carcinoma b. microcystic adnexal carcinoma c. porocarcinoma d. spiradenocarcinoma e. hidradenocarcinoma f. mucinous carcinoma g. digital.

The most frequent type is lateral transformation, extremely rare before puberty, reminiscent of a superficial spreading melanoma (SSM) ex-nevus. Deep nodular transformation is much rarer, can. A trizonal histologic pattern, consisting of a scar, junctional melanocytic proliferation and residual dermal melanocytes, has been described (Fig. 7). Malignant melanoma with regression is a major pitfall of this entity. The overlapping histologic features include epidermal pagetoid spread, irregularly distributed melanocytic nests and single. Primary cutaneous melanoma accounts for approximately 3% of all malignant skin tumors but contributes to most skin cancer-related deaths. 1 There are treatment options for most melanomas.

Huntsman Cancer Institute. (2021, May 11). New research outlines a critical driver in an immune cell's defense against melanoma. ScienceDaily. Retrieved July 31, 2021 from www.sciencedaily.com. • Malignant melanoma or melanocarcinoma is the malignant counterpart of naevus and is the most rapidly spreading malignant tumour of the skin, mucosa and other melanin containing sites. 5. Basal Cell Carcinoma GROSS FEATURES • Tumour is commonly a nodular growth with central ulceration (nodulo-ulcerative)

Superficial Spreading Melanoma - an overview

DOI: 10.4236/ojpathology.2018.83011 95 Open Journal of Pathology This entity is important to recognize as melanocytic matrical carcinoma can mimic melanoma when melanocytic proliferations or melanin pigment are prominent [8]. Here, we report an additional case of malignant melanocytic ma Protocol for the Examination of Specimens From Patients With Melanoma of the Skin . Version: Melanoma 4.0.1.0 Protocol Posting Date: June 2017 Includes pTNM requirements from the 8th Edition, AJCC Staging Manual. For accreditation purposes, this protocol should be used for the following procedures AND tumor types 0:00 / 13:35. Live. •. We can show melanoma with each of the structures mentioned below but most melanomas have a mixture of structures or clues and several colours. With that in mind consider the following examples and also look again at the video on Clues to Melanoma. Melanoma as thickened lines reticular Malignant Melanoma: this chapter outlines the incidence, risk factors, clinical presentation, investigations, treatments and prognosis of cancer at this anatomical site. These features are correlated with the core data that are required to make the corresponding histopathology reports of a consistently high quality, available in an appropriate.

Pathology Outlines - Vulvar melanomaPathology Outlines - Melanoma

Melanocytic matricoma pathology DermNet N

Dataset for histopathological reporting of primary

The staging for the progression of mucosal melanoma is vague because of how rare this type of melanoma is. The staging and survival rates vary based on the location of the mucosal melanoma 1. Introduction. Cutaneous malignant melanoma is the deadliest primary skin cancer. The incidence and mortality figures for malignant melanoma have continued to rise in the UK, US, Australia, New Zealand, and Western Europe over the past decades [1, 2].Atypical forms of cutaneous malignant melanoma can prove diagnostically difficult for both clinicians and histopathologists Lentigo maligna is where melanocyte cells have become malignant and grow continuously along the stratum basale of the skin, but have not invaded below the epidermis. Lentigo maligna is not the same as lentigo maligna melanoma, as detailed below.It typically progresses very slowly and can remain in a non-invasive form for years. It is normally found in the elderly (peak incidence in the 9th. Choroidal melanoma pathology outlines. Fig. 142.1 Choroidal melanoma (molecular profile class I) in a 43-year-old woman. (A) On gross examination, a heavily pigmented uveal melanoma is present. (B) The extracellular matrix pattern of the tumor with vascular loops and arches is detected with a PAS stain (PAS, ×4)

Mucosal melanoma of the nasal cavity and paranasal sinuse

Epidermotropic metastatic malignant melanoma (EMMM) is a well-recognized entity that can simulate primary malignant melanoma, and in the past reports of numerous (> or = 100) such lesions were. Pathology Surgical Pathology Images Histology Micrograph Gross Path Histo Cytology Meningitis Alzheimer Type II astrocytes Gunshot wound, tattoo pigment Chondroblastoma Chondromyxoid Fibroma Chondrosarcoma, Conventional Acral Lentiginous Melanoma, Nodular Type Melanoma,. Superficial spreading melanoma, also known as SSM, is one of the most common types of melanoma accounting for almost 70% of all diagnosed cases. It is the leading cause of cancer among young adults and can appear anywhere on the body, but tends to develop on the upper body of males and the lower legs of females STOMACH PATHOLOGY. 2. NORMAL ANATOMY/ HISTOLOGY. 3. GASTRITISInflammation of gastric mucosa Acute Gastritis Chronic Gastritis. 4. Acute GastritisTransient mucosal acute inflammationFrequently associated with: Heavy use of NSAIDs Excessive Alcohol consumption Heavy smoking Chemotherapeutic drugs Uremia Systemic infections (Salmonella, CMV.